General information

Reference

2024-166

Information about Molecular Partners AG

Molecular Partners AG is a clinical-stage biotech company pioneering the design and development of DARPin therapeutics for medical challenges other drug modalities cannot readily address. Founded in 2004 by a group of PhD students from the University of Zurich, we are a team of about 180 dedicated and passionate colleagues with operations in Switzerland and the U.S. DARPin (Designed Ankyrin Repeat Protein) therapeutics are a new class of custom-built protein drugs based on natural binding proteins that open new dimensions of multi-functionality and multi-target specificity in drug design.

DARPin therapeutics have been clinically validated across several therapeutic areas, including oncology, ophthalmology and virology, and we have programs in various stages of pre-clinical and clinical development, spanning immuno-oncology and targeted Radio-DARPin therapy.

Through our 20 years of leadership and experience with DARPins, as well as through partnerships with leading pharmaceutical companies such as Novartis and Orano Med, we are committed to bringing novel, life-changing therapies to patients.

We seek passionate, creative, and dynamic individuals to join us on our mission.

Position description

Position title

Research Associate Cell Line Development

Job description

We are seeking a skilled Research Associate to join our Cell Line Development team. This role will contribute technically and scientifically to the advancement of multiple projects, as well as bring innovation to our Cell Line Development team. This diverse position will include the following responsibilities:

• Contribute to the maintenance of an internal cell line bank, including banking of new cell lines and ensuring the quality of cell lines for Research purposes;
• Develop and engineer new cell lines with different approaches (transfection, lentiviral transduction, CRISPR/Cas9-based techniques);
• Assessment and quantification of target antigen expression;
• Design and perform cell based assays, such as cell binding, to support DARPin screening and Mode of Action studies;
• Contribute to improvement of processes and techniques;
• Identify and work with CROs where applicable;
• Analysis and interpretation of data and presentation to internal stakeholders;
• Maintain a close collaboration with cross-functional project teams;
• Maintain accurate and timely up-to-date documentation (eLN, FreezerWorks) in English;
• Update and optimization of local guidelines / SOPs for the Cell Culture team in English;
• In addition, you will contribute to the rotation system for the cleaning and maintenance of the Tissue Culture room, stock refill, PBMC isolation and maintenance and inventory of all the -80°C freezers and Liquid Nitrogen tanks.

Requirements

For this position, we are looking for a highly motivated individual bringing along:

• A Master degree in Biology or equivalent;
• Previous experience in industry is a plus;
• Extensive hands-on experience with mammalian cell culture methods, hands-on work with primary human cells is a plus;
• Required hands-on experience in:
  • Transfection, transduction
  • CRISPR
  • Flow Cytometry
• Careful and accurate working style, quality awareness;
• Full professional proficiency in English;
• MS-Office computer skills (Windows, Office, in particular Excel, Word, Outlook and Teams);
• Data analytic software, such as GraphPad Prism;
• FreezerWorks is a plus;
• Flexible and independent working attitude;
• Adapts successfully to changing situations and environments;
• Strong willingness to learn;
• Well-developed communication, team and organizational skills;
• Proactive personality and drive to optimize workflows.

This position summary is not intended to be all inclusive. An employee may perform other related duties as negotiated to meet the ongoing needs of the organization.

Our offer

Partnership and collaboration are at the core of our company, our research activities and our product candidates. Molecular Partners offers an international working environment and the opportunity to collaborate with outstanding individuals from numerous disciplines, who contribute to our shared goals of moving beyond boundaries, focusing on what matters, and contributing to our community. We foster true innovation and creative thinking to advance our therapeutic product candidates and continue to be inspired by the difference we can make for our patients. At Molecular Partners you will discover a challenging job, inspiring colleagues and a true purpose. If you are interested in working at Molecular Partners, we are looking forward to hearing from you!

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Position location

Job location

Switzerland, Zürich, Schlieren

Preferred head hunter clause

Please note Molecular Partners AG operates a list of preferred recruitment partners. For those partners who have no valid, signed agreement in place with Molecular Partners AG, all unsolicited resumes, CVs, anonymous profiles, or any other candidate details submitted through our website or to personal e-mail accounts of employees of Molecular Partners AG (including any of its subsidiaries, affiliates or related companies) are not subject to payment of any form of introduction, placement or referral fees.

Molecular Partners AG, Wagistrasse 14, CH-8952 Zurich-Schlieren, Switzerland.

www.molecularpartners.com