Postdoctoral Position in Molecular Systems Biology

100%, Zurich, fixed-term

We are seeking a Postdoctoral researcher for a project on the conservation of bacterial transcriptional regulatory networks.

Project background

Pseudomonas aeruginosa, the leading cause of mortality in cystic fibrosis patients and the fifth deadliest cause of bacterial infections, thrives as a bacterial pathogen due to its high adaptability and complex transcriptional regulatory networks. Despite its critical role, this regulatory network is still mostly uncharacterized and in most cases we do not know how variable it is between strains of P. aeruginosa and how network variability affects the establishment of infections.

Job description

The goal of this project is to assess the conservation of transcription factors functions across Pseudomonas aeruginosa strains. To that aim, the successful applicant will apply our recently-developed set of high-throughput methods for the characterization of transcriptional regulatory networks across a range of strains selected to represent the species vast genetic diversity. This will be done with a focus on transcription factors and their interactions with DNA using methods including ChIP-seq and DAP-seq.

The starting date is May 1st, 2025. The duration of employment is 1 year, with possibility of extension depending on fundings. The successful applicant will receive support to apply for own funding.

Profile

Essential:

• Strong laboratory experience with molecular biology
• Excellent communication skills in English
• Basic programming skills

Desirable:

• Experience with in vitro protein assays
• Experience with sequencing data analysis

Key personal characteristics:

• Commitment to actively participate and promote a positive lab environment
• Willingness to participate in interdisciplinary collaborations

Workplace

Workplace

We offer

The lab of Julian Trouillon will start at the Institute of Molecular Systems Biology at ETH Zürich in May 2025. Our research involves developing high-throughput genome-wide methodology to study transcription factors regulatory networks. The overarching goal is to understand how transcription factors drive decision-making in bacterial pathogens and use this knowledge to develop new therapeutic strategies.

As part of the world-renowned ETH Zürich, the Institute of Molecular Systems Biology (IMSB) offers an exceptional work environment dedicated to pioneering research in systems biology. At IMSB, you will be part of a dynamic team that leverages state-of-the-art facilities, fosters a collaborative atmosphere, and encourages professional growth.

We offer

• Direct access to state-of-the-art sequencers and mass spectrometers
• Ability to work on high-impact research topics
• Possibility to participate in interdisciplinary conferences
• Training in high-throughput sequencing assays

We value diversity

In line with our values, ETH Zurich encourages an inclusive culture. We promote equality of opportunity, value diversity and nurture a working and learning environment in which the rights and dignity of all our staff and students are respected. Visit our Equal Opportunities and Diversity website to find out how we ensure a fair and open environment that allows everyone to grow and flourish.

Curious? So are we.

We look forward to receiving your online application by 31st of December 2024. with the following documents:

• Motivation letter, including a description of specific interests for this position and of previous research experiences
• Curiculum vitae, including list of publications
• Contact information of 2-3 references

Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered.

Further information about the Institute of Molecular Systems Biology can be found on our website https://imsb.ethz.ch/. Questions regarding the position should be directed to Julian Trouillon, email jtrouillon[at]ethz.ch (no applications).