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Since being founded in 1815, Universitätsklinikum Erlangen has offered medicine of the highest standard and incorporated the latest insights from medical research and state-of-the-art equipment into diagnosis and therapy. More than 9,600 employees from approximately 50 different occupations are needed to provide the wide range of services offered by Universitätsklinikum Erlangen, ensuring our patients receive the very best care around the clock.

A postdoctoral position is available in the group of Professor Felix B. Engel. The group is highly interdisciplinary and international (3 postdocs, 8 PhDs, 7 technicians). We utilize a large variety of tools such as zebrafish and mouse as model organisms, 3D printing of tissues, hiPSCs, as well as state-of-the-art molecular and cell biology techniques. The Engel group is located in the Translational Research Center of the University Hospital Erlangen. Our laboratory publishes r

Your tasks:
Background of the project: This position is integrated in the research consortium PERCOLATE.
The overall aim of PERCOLATE is to establish a rapid and easy-to-use diagnostic test panel, based on detection of functional autoantibodies targeting G-protein coupled receptors (GPCR-fAAb) in combination with GPCR-fAAb mediated ischaemia-reperfusion parameters, accompanied by profiling of immune cells and viral reactivation in patients with Long-COVID (LC) and Post-Vaccination Syndrome (Post-VAC) for a personalized patients’ stratification and care. Your task will be to advance the method of Wallukat et al., in which primary rat cardiomyocytes were used, to detect the functional active GPCR-AAbs from patients’ sera utilizing hiPSC-derived cardiomyocytes and/or cardiac tissues. Aim 1. Establishment of a hiPSC-derived reporter cell line for fluorescence visualization of GPCR activation by GPCR-fAAbs in hiPSC-cardiomyocytes. Aim 2: Establishment of a hiPSC cell

Comments:
Funding: The project is funded by the Ministry of Health. Salary: E13, 100% for 2 years with possible extension (funded until 31.12.2028).

Essential experience/qualifications:
We are seeking a highly motivated and ambitious postdoctoral candidate with a PhD in cell biology, molecular biology, tissue engineering or similar, a strong background in cell and molecular biology with experience in life cell imaging, hiPSCs/hiPSC-cardiomyocytes and/or GPCR biology to join our team. Very good English language skills are mandatory

Additionally beneficial are:
Cardiac tissue engineering, 3D-printing, immunofluorescence analysis, first author publications in high profile journals

We offer:
A secure, interesting position as part of a motivated, open team
A thorough and qualified induction, and support in your new challenge.
Varied and responsible tasks with individual opportunities to grow and develop as a professional
A wide range of services for promoting a healthy lifestyle
All public service benefits, including supplementary benefits from the Federal and State
Government Pension Fund (VBL).
A family friendly environment and, if applicable, places in University accommodation
Professional experience can be taken into account when calculating total period of employment

Wir zählen zu den besten Krankenhäusern Deutschlands und sind einer der größten Arbeitgeber in Mittelfranken. Diesen Erfolg erarbeiten tagtäglich unsere über 9.600 hoch qualifizierten Beschäftigten in unterschiedlichsten Berufen. Wir als Uniklinikum Erlangen wissen, dass alle unsere Beschäftigten wichtig sind, damit auch in Zukunft modernste Medizin, ausgezeichnete Forschung und Patientenversorgung auf höchstem Niveau gelingen.

Wenn Sie sich eine Tätigkeit mit einem hohen sozialen Wert wünschen und die Welt der Spitzenmedizin mit uns gemeinsam gestalten und ermöglichen möchten, dann sind Sie bei uns richtig!

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